WebClinicians are often left with an uncertainty on the choice of antibiotic when a SPICE organism is isolated. The purpose of this study was to evaluate the outcomes of … WebGuidance from the IDSA suggests ‘caution if prescribing piperacillin-tazobactam for serious infections caused by organisms at high risk of significant AmpC production’ and that the preferred antibiotic should be cefepime or a carbapenem.6A recent pilot, randomized trial, albeit limited by lack of power, identified no difference in clinical …
Cefepime use for ESBL infections: Usable or Inducible?
WebMar 6, 2024 · Cefepime is not inferior to carbapenems overall in an adjusted analysis. Cefepime is inferior to carbapenems for cefepime MICs 4–8 μg/mL, but when confirmed … WebJan 1, 2024 · When a SPICE organism has been isolated, clinicians are often left with uncertainty in deciding which antibiotic to prescribe. To further complicate decision … ranczo u mara
AmpC β-Lactamases - PMC - National Center for Biotechnology …
WebDec 28, 2009 · Cefepime is a commonly used broad-spectrum cephalosporin with potent activity against a wide variety of Gram-negative bacteria, including Pseudomonas aeruginosa ().Despite its extensive use, its presence in multiple clinical guidelines, and numerous indications for its use (1, 16, 20, 26), a recent meta-analysis found treatment … WebJul 11, 2016 · A small retrospective study of patients with infection due to SPICE organisms (about 50% with bacteremia) found cefepime to be as effective as meropenem, but … WebSep 15, 2024 · A small retrospective study of patients with infection due to SPICE organisms (about 50% with bacteremia) found cefepime to be as effective as meropenem, but cautioned its use when adequate source control has not been achieved (3). Fluroroquinolones and aminoglycosides may also be considered. References dr kavitha uma ratnalingam