Off-target detection
Webb19 apr. 2024 · By screening a panel of potential RNA guides in cultured patient-derived cells, it may be possible to identify off-target sites that might have otherwise been … Webb1 sep. 2024 · The off-target effect is one of the major factors that limit the application of CRISPR/Cas9 system in therapeutics. Though this off-target activity has been reported …
Off-target detection
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Webb19 jan. 2024 · Comprehensive detection of on- and off-target mutations. Sometimes the smallest action can have unintended consequences, like the proverbial flap of a … Webb2 nov. 2024 · First, we benchmarked 10 available genome-wide off-target cleavage site (OTS) detection techniques with the published OTS detection datasets. Second, …
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