Determing c-myb protein level can isolate
WebThe 48-kDa v-Myb protein is truncated relative to the normal 75-kDa c-Myb protein at both its amino and carboxyl termini (Figs. 1 and 2) (Gerondakis and Bishop, 1986; Rosson and Reddy, 1986). In addition, v-Myb contains 10 amino acid substitutions relative to the homologous region of c-Myb (a previously described eleventh substitution was not ... WebThe transcription factor c-Myb was originally identified as a transforming oncoprotein encoded by two avian leukemia viruses. Subsequently, through the generation of mouse models that affect its expression, c-Myb has been shown to be a key regulator of hematopoiesis, including having critical roles in hematopoietic stem cells (HSCs). The …
Determing c-myb protein level can isolate
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WebDec 2, 2009 · Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Sakamoto H, Takeda N, Arai F, Hosokawa K, Garcia P, Suda T, Frampton J, Ogawa M. Stem Cells, 33(2):479-490, 01 Feb 2015 Cited by: 4 articles PMID: 25329760 WebDetermining c-Myb Protein Levels Can Isolate Functional Hematopoietic Stem Cell Subtypes HIROSHI SAKAMOTO,a NAOKI TAKEDA,b FUMIO ARAI,c KENTARO …
WebThis protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] ... WebOct 7, 2010 · It is known that c-Myb expression can be modified by the estrogen receptor, and c-Myb protein levels are increased in ER+ tumors , , . Indeed, twenty years ago Guerin and colleagues described a correlation linking high c-Myb levels with several good prognostic features, such as low tumor grade, ER+ status, and an anti-correlation to poor ...
WebUsing this reporter line we demonstrate that subtypes of HSCs can be isolated based upon their respective c-Myb protein expression levels. HSCs expressing low levels of c-Myb … WebFeb 1, 2015 · The transcription factor c-Myb was originally identified as a transforming oncoprotein encoded by two avian leukemia viruses. Subsequently, through the generation of mouse models that affect its expression, c-Myb has been shown to be a key regulator of hematopoiesis, including having critical roles in hematopoietic stem cells (HSCs).
WebAug 1, 2008 · TLDR. Analysis of c-myb gene transcriptional regulation using two cell lines modeling normal hematopoietic progenitor cells and transformed myelomonocytic blasts …
WebOct 14, 2015 · miR-150 preferentially targets c-Myb protein levels in C2C12 myoblasts. ... Sakamoto, H. et al. Determining C-Myb Protein Levels can Isolate Functional … sig both earsWebDetermining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Hiroshi Sakamoto, Naoki Takeda, Fumio Arai, Kentaro Hosokawa, Paloma … sig buckmark scopeWebOct 20, 2014 · The transcription factor c-Myb was originally identified as a transforming oncoprotein encoded by two avian leukemia viruses. Subsequently, through the … sigborn investment groupWebDetermining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Stem Cells. 2015; 33: 479-490. Crossref; PubMed; Scopus (7) Google Scholar). The correlations between G 0 M and these genes might not be detected because all these genes showed low RPKM (reads per kilobase of transcript per million mapped reads) … sig brewing tacoma waWebAlthough c-Myb expression has been reported in the skin, colon, respiratory tract, retina, testes, primary fibroblasts, and endothelial cells, the protein is most readily detected in immature hematopoietic precursors at high levels. These levels of c-Myb decrease as cells progress toward terminal differentiation (17, 27, 54, 63). Alterations in ... sig both eyesWebOct 14, 2015 · trol levels (Fig. 2B), while c-Myb protein levels were almos t extinguished (Fig. 2C). ese results indicate that miR-150 pr eferentially targets c-M yb translation. Low levels of miR -150 in RMS ... sigbrit bachWebOct 14, 2015 · For instance, hematopoietic stem cells differing in c-Myb protein levels more than 2-fold exhibit no more than 1.3-fold difference in c-myb mRNA levels 35. ... Sakamoto H. et al. Determining C-Myb Protein Levels can Isolate Functional Hematopoietic Stem Cell Subtypes. Stem Cells, 10.1002/stem.1855 (2014). sig broadmeadows