Cryptic relatedness
WebSep 2, 2005 · Cryptic relatedness refers to the idea that some members of a case-control sample might actually be close relatives, in which case their genotypes are not … WebDec 20, 2011 · Cryptic relationships such as first-degree relatives often appear in studies that collect population samples such as the case–control genome-wide association …
Cryptic relatedness
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WebOct 26, 2015 · Cryptic Relatedness in Epidemiologic Collections Accessed for Genetic Association Studies: Experiences From the Epidemiologic Architecture for Genes … WebNational Center for Biotechnology Information
WebJul 14, 2010 · In cryptic relatedness, relationships between individuals in the sample are typically either completely known (for example, pedigrees or families are available) or … WebMar 16, 2011 · Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean ...
WebPC-AiR performs a Principal Components Analysis on genome-wide SNP data for the detection of population structure in a sample that may contain known or cryptic relatedness. Unlike standard PCA, PC-AiR accounts for relatedness in the sample to provide accurate ancestry inference that is not confounded by family structure. WebJan 1, 2010 · Cryptic relatedness occurs when, for unforeseen reasons, pairs or groups of individuals are more closely related to each other than the population average - thus indicating they are close family members. Sample duplicates can also be treated as an extreme case of cryptic relatedness. Individuals that are closely related induce a …
WebSep 29, 2024 · Abstract Knowledge of biological relatedness between samples is important for many genetic studies. In large-scale human genetic association studies, the estimated kinship is used to remove cryptic relatedness, control for …
WebSep 4, 2011 · The problem of confounding by population structure, family structure and cryptic relatedness in genome-wide association studies (GWAS) is widely appreciated 1,2,3,4,5,6,7.Statistical methods for ... dose of brevipil in childrenWebcryptic relatedness in linkage or association studies with family data, population sample, or both, whereas PLINK is primarily suitable for detecting cryptic relatedness in GWAS with population ... city of roseville michigan assessingWebCryptic relatedness not only creates increased type 1 error rate but also affects other aspects of GWAS, such as population stratification via principal component … city of roseville limitsWebSep 2, 2005 · Furthermore, cryptic relatedness may be a serious concern in founder populations that have grown rapidly and recently from a small size. As an example, we analyze the impact of excess relatedness ... city of roseville michigan dpwWebMay 3, 2024 · Large-scale human genetics studies are ascertaining increasing proportions of populations as they continue growing in both number and scale. As a result, the amount of cryptic relatedness within these study cohorts is growing rapidly and has significant implications on downstream analyses. We demons … dose of cbd gummiesWebcryptic relatedness. In Section 2 we discuss defini-tions and estimators of the kinship coefficients that are central to our review of methods of correcting for confounding by … city of roseville mi assessor\u0027s officeWebCryptic relatedness was addressed by removing one individual of each pair for which pihat> 0.2. To define individuals of primarily European ancestry we used FlashPCA2 combined with CEU, YRI, and CHB reference sets from the 1000 genomes project phase 3 spiked in and the Europeans were selected. The cut-off for the European subset was … city of roseville michigan assessor