Brd2 compartmentalizes the accessible genome
WebThe bromodomain containing 2 (BRD2) gene has been recently shown to have an active role in the accessible genome organization and to promote the spatial mixing and compartmentalization of... WebApr 11, 2024 · While the formation of TADs is dependent on cohesin, the mechanism behind compartmentalization remains enigmatic. Here, we show that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes spatial mixing and compartmentalization of active chromatin after cohesin loss.
Brd2 compartmentalizes the accessible genome
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WebApr 11, 2024 · While the formation of TADs is dependent on cohesin, the mechanism behind compartmentalization remains enigmatic. Here, we show that the bromodomain and … WebBRD2 compartmentalizes the accessible genome. Nature Genetics. 2024-04 Journal article. DOI: 10.1038/s41588-022-01044-9. Contributors : Liangqi Xie; Peng Dong; …
WebSelected Publications (also see google scholar). Lange J, Rose J, Chen C, Pichugin Y, Xie L, …, Mischel P (2024).The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature Genetics. 2024 Sep 19. doi: 10.1038/s41588-022-01177-x; Xie L, Dong P, Qi Y,…, Zhang B, Tjian R, Liu Z (2024). BRD2 Compartmentalizes the Accessible … WebHere, we show that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes spatial mixing and compartmentalization of active chromatin after …
WebEcosystem 2.0 in action. In theory, participating successfully in ecosystems or orchestrating them can sound like a high-wire act. In practice, it may not feel as daunting. Let’s look at … WebSeasonal Variation. Generally, the summers are pretty warm, the winters are mild, and the humidity is moderate. January is the coldest month, with average high temperatures …
Webby BRD2 Yubao Cheng1 and Siyuan Wang 1,2,3,4,5,6,7,8,* Themolecularmechanismunderly-ing 3D genome compartmentaliza-tion remains a mystery. Xie et al. found that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes the com-partmentalization of the accessible chromatin domains after cohesin …
WebBRD2 compartmentalizes the accessible genome. View PDF In Nature Genetics on 1 April 2024 by Xie, L., Dong, P., et al.. Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin. View PDF In Nature Communications on 23 March 2024 by Rivera, C., Lee, H. G., et al.. jessica hughes 303 magazineWebDec 1, 2024 · Models chromatin compartmentalization by BRD2. Compartment A and B regions of chromatin are shown in red and blue, respectively. (A) The different functions of BRD2 and BRD4 in chromatin organization and transcription regulation. (B) Loop extrusion-dependent A–B compartment conversion upon BRD2 loss. jessica hu md mghWebBRD2 Compartmentalizes the Accessible Genome Article Full-text available Apr 2024 Liangqi Xie Peng Dong Yifeng Qi [...] Zhe Liu Mammalian chromosomes are organized into megabase-sized... lâmpadas ikeaWebWhile the formation of TADs is dependent on cohesin, the mechanism behind compartmentalization remains enigmatic. Here, we show that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes spatial mixing and compartmentalization of active chromatin after cohesin loss. jessica hugesWebPMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal … lampadas i30 2012WebSpatial organization of the 3D genome encodes gene co-expression programs in single cells. View PDF. Preprint on BioRxiv : the Preprint Server for Biology on 27 October 2024 by Dong, P., Zhang, S., et al.. BRD2 compartmentalizes the accessible genome. jessica hwei-jay fan npiWebMay 5, 2024 · BRD2 facilitates mixing and compartmentalization of active chromatin upon cohesin depletion. BRD2’s function is counteracted by cohesin and BRD4. Liangqi Xie Peng Dong Zhe Liu Article 11 Apr... jessica hung md